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KMID : 0360120130350010013
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Journal of the Korean Society of Maxillofacial Plastic Reconstructive Surgeons
2013 Volume.35 No. 1 p.13 ~ p.17
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The Effect of Silk Fibroin Particles Coated with Hydroxyapatites on Bone Regeneration in the Rat Calvarial Defect Model
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Seok Hyun
Park Yong-Tae
Kim Seong-Gon
Jin Hyung-Joon
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Abstract
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Purpose: This study evaluated the capability of bone formation of silk fibroin particles coated with hydroxyapatites (HA/SF), as bone graft material when put into the calvarial defect of rats.
Methods: Twenty Sprague Dawley rats were used for this study and round shaped defects were formed in the center of parietal bones (diameter: 8.0 mm). The defect was filled with (1) HA/SF (experimental group), or (2) left as a vacant space (control group). The animals were sacrificed at 4 or 8 weeks, postoperatively. The specimens were decalcified and stained with Masson’s trichrome for histomorphometric analysis.
Results: The average of new bone formation was $33.18{\pm}3.10%$ 수식 이미지 in the experimental group and $20.49{\pm}5.79%$ 수식 이미지 in the control group at 4 weeks postoperatively. That was $42.52{\pm}7 수식 이미지.74%$ 수식 이미지 in the experimental group and $25.50{\pm}7.31%$ 수식 이미지 in the control group at 8 weeks postoperatively. The difference between the groups was significantly higher at both 4 weeks and 8 weeks postoperatively (P<0.05).
Conclusion:The rat calvarial defect was successfully repaired by HA/SF graft. The HA/SF graft showed more new bone formation compared with the unfilled control.
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KEYWORD
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Silk fibroin, Hydroxyapatite, Bone regeneration, Rat calvarial defect
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